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Imagine
you are given the lego blocks of life to build protein
models...
ProteinShop
helps you put those blocks together,
first connecting
them like beads in a necklace,
then
assembling groups or mega-blocks: alpha-
helices,
beta-sheets, and coils,
and finally folding them into the compact shape that corresponds to their functional form, the shape they must adopt to perform their function.
ProteinShop is a powerful molecular modeling program that combines interactive features and visualization capabilities developed to guide the manual design of protein structures.
ProteinShop lets you use your knowledge and intuition to select beta-strands and arrange them to form desired beta-sheets or to select alpha-helices and pack them to form desired folds.
Furthermore, ProteinShop provides automatic tools to help you in the process.
ProteinShop was designed to bring interactive computing graphics into the field of protein structure prediction to a level not attempted by other visualization tools. It was motivated by our conviction that only such level of interaction will help scientists simulate the folding, behavior, and interactions of molecules on computers, learn about the complex biological systems at hand, and ultimately accelerate time to solution. ProteinShop's initial goal was to streamline and simplify the process of creating a variety of protein structures by manipulating the proteins as if we could grab them with our own hands, using an energy function to guide the process.
ProteinShop was developed at the Lawrence Berkeley National Laboratory by researchers from Lawrence Berkeley National Laboratory, University of California at Davis, and Lawrence Livermore National Laboratory.
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